An issue/problem I’ve experienced recently with VS Unit Testing & SharePoint OM Mode. It is impossible to run VS Unit Tests that connect to the OM on a 64bit machine. Reason is that Visual Studio is a native 32bit app and since it runs in splwow64 mode, it cannot connect to a WSS 64bit process. 32bit & 64bit COM dlls can't mix.
Just Something to observe if you get an error similar to
Test method AiE.UnitTests.WorkshopBusinessRulesTest.UpdateWorkshopInstanceTest threw exception: System.ApplicationException: Problem Accessing SharePoint site ---> System.IO.FileNotFoundException: The Web application at http://localhost:3333/workshops could not be found. Verify that you have typed the URL correctly. If the URL should be serving existing content, the system administrator may need to add a new request URL mapping to the intended application..